Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 12/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | F2 | P00734 | 4/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13461888 | 0.82 | F10 (0.55) | F10KMT2ASMN1; SMN2MEN1GAA | |
| SCHEMBL3309272 | 0.81 | F10 (0.51) | F10KMT2AMEN1F2MAPK1 | |
| SCHEMBL3309265 | 0.81 | F10 (0.51) | F10KMT2AMEN1F2MAPK1 | |
| SCHEMBL8259083 | 0.79 | MAPK1 (0.47) | F10MAPK1LMNAGSK3B | |
| SCHEMBL3545702 | 0.76 | F10 (0.57) | F10KMT2ASMN1; SMN2MEN1GAA | |
| SCHEMBL3450499 | 0.76 | F10 (0.47) | F10KMT2ASMN1; SMN2MEN1RAB9A | |
| SCHEMBL8305363 | 0.75 | F10 (0.54) | F10KMT2ASMN1; SMN2MEN1GAA | |
| SCHEMBL4691317 | 0.75 | F10 (0.54) | F10KMT2ASMN1; SMN2MEN1GAA | |
| SCHEMBL8354818 | 0.75 | F10 (0.54) | F10KMT2ASMN1; SMN2MEN1GAA | |
| SCHEMBL8257466 | 0.75 | SMN1; SMN2 (0.49) | F10KMT2ASMN1; SMN2MEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7820699-B2 | Cyclic amines | HOFFMANN-LA ROCHE INC. (US) | 2010-10-26 | — | — | US | disclosed |
| US-7820699-B2 | Cyclic amines | HOFFMANN-LA ROCHE INC. (US) | 2010-10-26 | — | — | US | disclosed |
| WO-2006114401-A2 | NOVEL CYCLIC AMINES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-11-02 | — | — | WO | disclosed |