Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR2 | P50052 | 6/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | HTR2C | P28335 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.44 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.44 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.44 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.44 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.44 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.44 |
| ▸ | PREP | P48147 | 2/20 | 0.44 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.43 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.43 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7651346 | 1.00 | AGTR2 (0.56) | AGTR2SMN1; SMN2NPC1RAB9AHTR2C | |
| SCHEMBL8350422 | 1.00 | AGTR2 (0.56) | AGTR2SMN1; SMN2NPC1RAB9AHTR2C | |
| SCHEMBL8351858 | 0.92 | AGTR2 (0.54) | AGTR2SMN1; SMN2NPC1RAB9AHTR2C | |
| SCHEMBL12798144 | 0.92 | AGTR2 (0.54) | AGTR2SMN1; SMN2NPC1RAB9AHTR2C | |
| SCHEMBL7646821 | 0.92 | AGTR2 (0.54) | AGTR2SMN1; SMN2NPC1RAB9AHTR2C | |
| SCHEMBL25125018 | 0.87 | HTR2C (0.61) | AGTR2SMN1; SMN2NPC1RAB9AHTR2C | |
| SCHEMBL8260516 | 0.86 | HTR2C (0.50) | AGTR2SMN1; SMN2NPC1RAB9AHTR2C | |
| SCHEMBL8795061 | 0.85 | PREP (0.64) | SMN1; SMN2NPC1RAB9ACYP2C19PREP | |
| SCHEMBL16276273 | 0.83 | HTR2C (0.49) | AGTR2SMN1; SMN2NPC1RAB9AHTR2C | |
| SCHEMBL14336080 | 0.82 | HTR2C (0.57) | AGTR2SMN1; SMN2NPC1RAB9AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006096807-A1 | AZA-BRIDGED-BICYCLIC AMINO ACID DERIVATIVES AS ALPHA 4 INTEGRIN ANTAGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-09-14 | — | — | WO | disclosed |