Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 5/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.36 |
| ▸ | MET | P08581 | 2/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.34 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.33 |
| ▸ | MTOR | P42345 | 2/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
| ▸ | TTK | P33981 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL823702 | 1.00 | HDAC1 (0.36) | HDAC1HDAC2METROCK2JAK2 | |
| SCHEMBL823651 | 0.88 | JAK2 (0.45) | HDAC1HDAC2JAK2JAK3GRM4 | |
| SCHEMBL825711 | 0.88 | JAK2 (0.45) | HDAC1HDAC2JAK2JAK3GRM4 | |
| SCHEMBL823650 | 0.85 | PIK3CA (0.37) | GRM4MAPK8MAPK9PIK3CAMTOR | |
| SCHEMBL825938 | 0.85 | PIK3CA (0.37) | GRM4MAPK8MAPK9PIK3CAMTOR | |
| SCHEMBL4423835 | 0.80 | MAPK1 (0.46) | JAK2GRM4MAPK8MAPK9PIK3CA | |
| SCHEMBL4423840 | 0.80 | ALOX5AP (0.38) | HDAC1HDAC2GRM4MAPK8MAPK9 | |
| SCHEMBL3609814 | 0.76 | HDAC1 (0.39) | HDAC1HDAC2GRM4PIK3CAMTOR | |
| SCHEMBL3605007 | 0.76 | HDAC1 (0.39) | HDAC1HDAC2GRM4PIK3CAMTOR | |
| SCHEMBL13500401 | 0.76 | HDAC1 (0.39) | HDAC1HDAC2GRM4PIK3CAMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143394-B2 | Pyrido(3,2-d)pyrimidines useful for treating viral infections | GILEAD SCIENCES, INC. (US) | 2012-03-27 | — | — | US | disclosed |