Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 2/20 | 0.38 |
| ▸ | FEN1 | P39748 | 2/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.35 |
| ▸ | GRM4 | Q14833 | 3/20 | 0.35 |
| ▸ | MTOR | P42345 | 2/20 | 0.35 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 5/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3609814 | 0.88 | HDAC1 (0.39) | ALOX5APFEN1PIK3CAGRM4MTOR | |
| SCHEMBL3605007 | 0.88 | HDAC1 (0.39) | ALOX5APFEN1PIK3CAGRM4MTOR | |
| SCHEMBL13500401 | 0.88 | HDAC1 (0.39) | ALOX5APFEN1PIK3CAGRM4MTOR | |
| SCHEMBL4423835 | 0.87 | MAPK1 (0.46) | ALOX5APFEN1PIK3CAGRM4MTOR | |
| SCHEMBL4421609 | 0.85 | MTOR (0.38) | PIK3CAGRM4MTORAKT1MAP4K4 | |
| SCHEMBL825938 | 0.82 | PIK3CA (0.37) | PIK3CAGRM4MTORMAP4K4MAPK8 | |
| SCHEMBL823650 | 0.82 | PIK3CA (0.37) | PIK3CAGRM4MTORMAP4K4MAPK8 | |
| SCHEMBL3612774 | 0.81 | HDAC1 (0.43) | ALOX5APFEN1PIK3CAMAP4K4HDAC1 | |
| SCHEMBL4421606 | 0.80 | CHEK2 (0.40) | GRM4MTORMAP4K4MAPK8MAPK9 | |
| SCHEMBL825985 | 0.80 | HDAC1 (0.36) | PIK3CAGRM4MTORMAPK8MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090324543-A1 | PYRIDO(3,2-d)PYRIMIDINES USEFUL FOR TREATING VIRAL INFECTIONS | GILEAD SCIENCES, INC (US) | 2009-12-31 | — | — | US | claimed |
| US-20090324543-A1 | PYRIDO(3,2-d)PYRIMIDINES USEFUL FOR TREATING VIRAL INFECTIONS | GILEAD SCIENCES, INC (US) | 2009-12-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090324543-A1 | PYRIDO(3,2-d)PYRIMIDINES USEFUL FOR TREATING VIRAL INFECTIONS | PNPO, DPYD, PLPBP | ALOX5AP 1388/4885FEN1 568/4885PIK3CA 1189/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.