Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 3/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | AKT1 | P31749 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 3/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2924682 | 1.00 | REN (0.43) | RENMTNR1AMAPTSMN1; SMN2NPC1 | |
| SCHEMBL2950514 | 0.92 | REN (0.42) | RENMAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL3464869 | 0.92 | REN (0.42) | RENMAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL2923834 | 0.90 | REN (0.37) | RENMAPTSMN1; SMN2AKT1KMT2A | |
| SCHEMBL13498080 | 0.90 | REN (0.37) | RENMAPTSMN1; SMN2AKT1KMT2A | |
| SCHEMBL2924312 | 0.90 | REN (0.36) | RENMAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL3465753 | 0.90 | REN (0.36) | RENMAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL3464431 | 0.90 | REN (0.36) | RENMAPTSMN1; SMN2THRBCYP3A4 | |
| SCHEMBL13498081 | 0.89 | REN (0.35) | RENMAPTTHRBCYP3A4CYP2C19 | |
| SCHEMBL3465071 | 0.89 | REN (0.35) | RENMAPTTHRBCYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006103277-A2 | 2 , 4 , 5-SUBSTITUTED PIPERIDINES AS RENIN INHIBITORS | SPEEDEL EXPERIMENTA AG (CH) | 2006-10-05 | — | — | WO | disclosed |