Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 7/20 | 0.65 |
| ▸ | CCNE1 | P24864 | 6/20 | 0.65 |
| ▸ | CDK5 | Q00535 | 6/20 | 0.65 |
| ▸ | PSEN1 | P49768 | 10/20 | 0.55 |
| ▸ | PSEN2 | P49810 | 10/20 | 0.55 |
| ▸ | APH1B | Q8WW43 | 10/20 | 0.55 |
| ▸ | NCSTN | Q92542 | 10/20 | 0.55 |
| ▸ | APH1A | Q96BI3 | 10/20 | 0.55 |
| ▸ | PSENEN | Q9NZ42 | 10/20 | 0.55 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CDK1 | P06493 | 1/20 | 0.48 |
| ▸ | CDK4 | P11802 | 1/20 | 0.48 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.48 |
| ▸ | CCND1 | P24385 | 1/20 | 0.48 |
| ▸ | CDK7 | P50613 | 1/20 | 0.48 |
| ▸ | CDK9 | P50750 | 1/20 | 0.48 |
| ▸ | CCNH | P51946 | 1/20 | 0.48 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5875523 | 1.00 | CDK2 (0.65) | CDK2CCNE1CDK5PSEN1PSEN2 | |
| SCHEMBL5875507 | 0.87 | PSEN1 (0.71) | CDK2CCNE1CDK5PSEN1PSEN2 | |
| SCHEMBL8257260 | 0.87 | PSEN1 (0.71) | CDK2CCNE1CDK5PSEN1PSEN2 | |
| SCHEMBL8258681 | 0.87 | CDK2 (0.55) | CDK2CCNE1CDK5PSEN1PSEN2 | |
| SCHEMBL5875482 | 0.87 | CDK2 (0.55) | CDK2CCNE1CDK5PSEN1PSEN2 | |
| SCHEMBL5875658 | 0.85 | PSEN1 (0.65) | CDK2CCNE1CDK5PSEN1PSEN2 | |
| SCHEMBL8258601 | 0.85 | PSEN1 (0.65) | CDK2CCNE1CDK5PSEN1PSEN2 | |
| SCHEMBL5836593 | 0.85 | CDK2 (0.70) | CDK2CCNE1CDK5PSEN1PSEN2 | |
| SCHEMBL27569831 | 0.85 | CDK2 (0.70) | CDK2CCNE1CDK5PSEN1PSEN2 | |
| SCHEMBL8258691 | 0.83 | PSEN1 (0.80) | CDK2CCNE1CDK5PSEN1PSEN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040152747-A1 | Thiazole compounds for treatment of neurodegenerative disorders | PFIZER INC | 2004-08-05 | — | — | US | disclosed |
| US-20040152747-A1 | Thiazole compounds for treatment of neurodegenerative disorders | PFIZER INC | 2004-08-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040152747-A1 | Thiazole compounds for treatment of neurodegenerative disorders | APP, PARK7, IAPP | CDK2 1792/4885CCNE1 1853/4885CDK5 506/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.