Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 3/20 | 0.48 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.37 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.37 |
| ▸ | TAS1R2 | Q8TE23 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP8 | P22894 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25486735 | 1.00 | EPHX1 (0.48) | EPHX1HSD11B1DRD2MEN1LMNA | |
| SCHEMBL103089 | 0.92 | HSD11B1 (0.47) | EPHX1HSD11B1DRD2RAB9ANPC1 | |
| Bicarbonate SCHEMBL8027977 | 0.88 | HSD11B1 (0.44) | EPHX1HSD11B1DRD2RAB9ANPC1 | |
| SCHEMBL12283083 | 0.85 | EPHX2 (0.52) | EPHX1HSD11B1DRD2RAB9ANPC1 | |
| SCHEMBL12282654 | 0.84 | EPHX1 (0.52) | EPHX1RAB9ANPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL12206723 | 0.84 | EPHX1 (0.47) | EPHX1HSD11B1DRD2RAB9ANPC1 | |
| SCHEMBL18814221 | 0.83 | HSD11B1 (0.42) | EPHX1HSD11B1DRD2KMT2ASMN1; SMN2 | |
| SCHEMBL13998252 | 0.83 | SMYD3 (0.49) | EPHX1HSD11B1DRD2 | |
| SCHEMBL18814220 | 0.83 | HSD11B1 (0.42) | EPHX1HSD11B1DRD2KMT2ASMN1; SMN2 | |
| SCHEMBL25480124 | 0.82 | EPHX1 (0.55) | EPHX1RAB9ANPC1ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8461328-B2 | Tricyclic heterocyclic compounds, compositions and methods of use thereof | GENENTECH, INC. (US) | 2013-06-11 | — | — | US | disclosed |
| WO-2006097293-A2 | COMBINATION OF A STEROID SULFATASE INHIBITOR AND AN ASCOMYCIN | NOVARTIS AG (CH) | 2006-09-21 | — | — | WO | disclosed |