Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 2/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.44 |
| ▸ | SMPD1 | P17405 | 4/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2438091 | 0.86 | PDE4D (0.53) | PDE4DPDE4BSMPD1PRSS1 | |
| SCHEMBL2439225 | 0.84 | PDE4D (0.53) | PDE4DPDE4BSMPD1 | |
| SCHEMBL3375161 | 0.84 | CA12 (0.58) | PDE4DPDE4BSMPD1PRSS1PDE4A | |
| SCHEMBL29555877 | 0.80 | PDE4D (0.62) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL11045658 | 0.80 | PDE4D (0.62) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL2441538 | 0.75 | PDE4D (0.57) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL2592347 | 0.75 | TSHR (0.62) | PRSS1 | |
| SCHEMBL13433959 | 0.74 | L3MBTL1 (0.52) | — | |
| SCHEMBL2589912 | 0.74 | MAPT (0.55) | SMPD1PRSS1 | |
| SCHEMBL16930080 | 0.73 | SMPD1 (0.51) | PDE4DPDE4BSMPD1PRSS1PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006100036-A1 | 3, 4-SUBSTITUTED PYRROLIDINE DERIVATIVES FOR THE TREATMENT OF HYPERTENSION | NOVARTIS AG (CH) | 2006-09-28 | — | — | WO | disclosed |