Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL2 | P60568 | 8/20 | 0.46 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.44 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 2/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.32 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.32 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.32 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.32 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.32 |
| ▸ | CSF1R | P07333 | 1/20 | 0.31 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | F10 | P00742 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8262095 | 0.90 | IL2 (0.58) | IL2STIM1ORAI1KCNQ3KCNQ2 | |
| SCHEMBL8261520 | 0.89 | IL2 (0.38) | IL2STIM1ORAI1CNR1RORC | |
| SCHEMBL8263046 | 0.88 | IL2 (0.48) | IL2STIM1ORAI1CNR1RORC | |
| SCHEMBL8261524 | 0.82 | IL2 (0.42) | IL2RORCCSF1RF10 | |
| SCHEMBL8256457 | 0.82 | IL2 (0.44) | IL2STIM1ORAI1KCNQ3KCNQ2 | |
| SCHEMBL8263057 | 0.80 | POLB (0.42) | IL2RORC | |
| SCHEMBL8263043 | 0.79 | IL2 (0.49) | IL2STIM1ORAI1 | |
| SCHEMBL8262619 | 0.78 | IL2 (0.56) | IL2STIM1ORAI1KCNQ3KCNQ2 | |
| SCHEMBL8264013 | 0.78 | IL2 (0.60) | IL2STIM1ORAI1KCNQ3KCNQ2 | |
| SCHEMBL8261522 | 0.77 | IL2 (0.37) | IL2STIM1ORAI1CNR1RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006081389-A1 | THIOPHENE COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP. (US) | 2006-08-03 | — | — | WO | disclosed |