Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL2 | P60568 | 5/20 | 0.38 |
| ▸ | ABL1 | P00519 | 3/20 | 0.37 |
| ▸ | STIM1 | Q13586 | 2/20 | 0.36 |
| ▸ | ORAI1 | Q96D31 | 2/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 2/20 | 0.33 |
| ▸ | F10 | P00742 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.32 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8261524 | 0.91 | IL2 (0.42) | IL2CYP11B2CSF1RF10RORC | |
| SCHEMBL8263043 | 0.91 | IL2 (0.49) | IL2ABL1STIM1ORAI1L3MBTL1 | |
| SCHEMBL8261516 | 0.89 | IL2 (0.46) | IL2STIM1ORAI1CNR1CSF1R | |
| SCHEMBL8261522 | 0.88 | IL2 (0.37) | IL2ABL1STIM1ORAI1CNR1 | |
| SCHEMBL8263042 | 0.88 | IL2 (0.40) | IL2ABL1STIM1ORAI1CNR1 | |
| SCHEMBL8260064 | 0.83 | IL2 (0.46) | IL2ABL1STIM1ORAI1CYP11B2 | |
| SCHEMBL8262105 | 0.82 | IL2 (0.47) | IL2ABL1CYP11B2CSF1RF10 | |
| SCHEMBL8262095 | 0.79 | IL2 (0.58) | IL2ABL1STIM1ORAI1 | |
| SCHEMBL8261521 | 0.79 | IL2 (0.41) | IL2CYP11B2CSF1RF10RORC | |
| SCHEMBL8262993 | 0.79 | IL2 (0.47) | IL2ABL1STIM1ORAI1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006081389-A1 | THIOPHENE COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP. (US) | 2006-08-03 | — | — | WO | disclosed |