Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 9/20 | 0.55 |
| ▸ | MAPT | P10636 | 6/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | CDK14 | O94921 | 7/20 | 0.54 |
| ▸ | CCNY | Q8ND76 | 7/20 | 0.54 |
| ▸ | NPC1 | O15118 | 6/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | GFER | P55789 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13993630 | 0.91 | CDK14 (0.53) | RAB9AMAPTSMN1; SMN2MAPK1LMNA | |
| SCHEMBL13993628 | 0.90 | LCK (0.61) | RAB9AMAPTSMN1; SMN2CDK14CCNY | |
| SCHEMBL955570 | 0.82 | CDK14 (0.46) | MAPTCDK14CCNY | |
| Hydrochloric Acid SCHEMBL953649 | 0.81 | CDK14 (0.46) | MAPTCDK14CCNY | |
| SCHEMBL8212885 | 0.80 | TYK2 (0.68) | CDK14CCNYMEN1KMT2AHTT | |
| SCHEMBL23271165 | 0.79 | CDK14 (0.56) | CDK14CCNY | |
| SCHEMBL13993686 | 0.79 | RAB9A (0.61) | RAB9AMAPTSMN1; SMN2LMNACDK14 | |
| SCHEMBL23271061 | 0.79 | CDK14 (0.65) | CDK14CCNY | |
| SCHEMBL13993631 | 0.79 | RAB9A (0.56) | RAB9AMAPTSMN1; SMN2MAPK1LMNA | |
| SCHEMBL13993629 | 0.78 | NPC1 (0.49) | RAB9ASMN1; SMN2NPC1LCKMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006077414-A1 | PYRAZOLE DERIVATIVES FOR THE INHIBITION OF CDK' S AND GSK' S | ASTEX THERAPEUTICS LIMITED (GB) | 2006-07-27 | — | — | WO | disclosed |