Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL2 | P60568 | 14/20 | 0.60 |
| ▸ | TNF | P01375 | 1/20 | 0.42 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.42 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.40 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.40 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4762919 | 0.96 | IL2 (0.64) | IL2TNFSTIM1ORAI1KIT | |
| SCHEMBL8263169 | 0.81 | IL2 (0.58) | IL2TNFSTIM1ORAI1MEN1 | |
| SCHEMBL5554267 | 0.79 | IL2 (0.63) | IL2STIM1ORAI1 | |
| SCHEMBL16471113 | 0.78 | IL2 (0.63) | IL2TNFSTIM1ORAI1MEN1 | |
| SCHEMBL4762593 | 0.78 | IL2 (0.41) | IL2STIM1ORAI1KDRTYK2 | |
| SCHEMBL4769130 | 0.78 | IL2 (0.68) | IL2TNFSTIM1ORAI1KIT | |
| SCHEMBL4724606 | 0.77 | IL2 (0.70) | IL2TNFSTIM1ORAI1KIT | |
| SCHEMBL8261671 | 0.77 | IL2 (0.66) | IL2TNFSTIM1ORAI1JAK2 | |
| SCHEMBL1828207 | 0.77 | IL2 (0.63) | IL2TNFSTIM1ORAI1MEN1 | |
| SCHEMBL4769509 | 0.76 | IL2 (0.65) | IL2TNFSTIM1ORAI1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006083477-A2 | COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP. (US) | 2006-08-10 | — | — | WO | disclosed |