Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL2 | P60568 | 13/20 | 0.58 |
| ▸ | TYK2 | P29597 | 3/20 | 0.55 |
| ▸ | JAK2 | O60674 | 2/20 | 0.55 |
| ▸ | JAK1 | P23458 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.55 |
| ▸ | TNF | P01375 | 1/20 | 0.45 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.45 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.45 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4766353 | 0.95 | IL2 (0.63) | IL2TYK2JAK2JAK1HTT | |
| SCHEMBL4768204 | 0.83 | IL2 (0.60) | IL2TYK2JAK2JAK1HTT | |
| SCHEMBL8261671 | 0.82 | IL2 (0.66) | IL2TYK2JAK2JAK1HTT | |
| SCHEMBL8263131 | 0.81 | IL2 (0.60) | IL2TYK2JAK2JAK1HTT | |
| SCHEMBL8193723 | 0.80 | TYK2 (0.62) | IL2TYK2JAK2JAK1HTT | |
| SCHEMBL1828207 | 0.80 | IL2 (0.63) | IL2TYK2JAK2JAK1HTT | |
| SCHEMBL16471113 | 0.80 | IL2 (0.63) | IL2TYK2JAK2JAK1HTT | |
| SCHEMBL4764906 | 0.79 | IL2 (0.60) | IL2TYK2JAK2JAK1HTT | |
| SCHEMBL4770059 | 0.79 | IL2 (0.62) | IL2TYK2JAK2JAK1HTT | |
| SCHEMBL16471123 | 0.79 | IL2 (0.62) | IL2TYK2JAK2JAK1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006083477-A2 | COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP. (US) | 2006-08-10 | — | — | WO | disclosed |