Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MKNK1 | Q9BUB5 | 5/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 5/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.33 |
| ▸ | SDHB | P21912 | 1/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5194991 | 0.92 | MAPT (0.46) | MAPTMKNK1MKNK2PTGDR2HRH3 | |
| SCHEMBL5439478 | 0.91 | MAPT (0.45) | MAPTMKNK1MKNK2PTGDR2HRH3 | |
| SCHEMBL5439520 | 0.88 | MAPT (0.46) | MAPTMKNK1MKNK2PTGDR2HRH3 | |
| SCHEMBL5197304 | 0.86 | MAPT (0.49) | MAPTMKNK1MKNK2PTGDR2TP53 | |
| SCHEMBL16275018 | 0.86 | MAPT (0.44) | MAPTMKNK1MKNK2PTGDR2HTR2A | |
| SCHEMBL5437171 | 0.86 | MAPT (0.44) | MAPTMKNK1MKNK2PTGDR2HRH3 | |
| SCHEMBL5439446 | 0.86 | MAPT (0.44) | MAPTMKNK1MKNK2PTGDR2HRH3 | |
| SCHEMBL5433606 | 0.86 | MAPT (0.44) | MAPTMKNK1MKNK2PTGDR2HRH3 | |
| SCHEMBL5183183 | 0.85 | MAPT (0.44) | MAPTMKNK1MKNK2PTGDR2HRH3 | |
| SCHEMBL5437175 | 0.85 | MAPT (0.50) | MAPTMKNK1MKNK2PTGDR2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006030032-A1 | NOVEL PYRIDINONE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2-RECEPTORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-03-23 | — | — | WO | disclosed |