Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | PTGDR2 | Q9Y5Y4 | 5/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.39 |
| ▸ | PPARD | Q03181 | 2/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5183183 | 0.91 | MAPT (0.44) | MAPTPTGDR2ALDH1A1MKNK1MKNK2 | |
| SCHEMBL5442869 | 0.89 | SMN1; SMN2 (0.43) | MAPTPTGDR2ALDH1A1MKNK1MKNK2 | |
| SCHEMBL5183820 | 0.89 | PTGS2 (0.44) | MAPTPTGDR2ALDH1A1MKNK1MKNK2 | |
| SCHEMBL8264094 | 0.86 | MAPT (0.47) | MAPTPTGDR2ALDH1A1MKNK1MKNK2 | |
| SCHEMBL5433959 | 0.85 | KLKB1 (0.42) | MAPTPTGDR2ALDH1A1MKNK1MKNK2 | |
| SCHEMBL5439520 | 0.85 | MAPT (0.46) | MAPTPTGDR2MKNK1MKNK2 | |
| SCHEMBL5194991 | 0.85 | MAPT (0.46) | MAPTPTGDR2MKNK1MKNK2HTR2A | |
| SCHEMBL5439478 | 0.84 | MAPT (0.45) | MAPTPTGDR2MKNK1MKNK2HTR2A | |
| SCHEMBL5442652 | 0.83 | MAPT (0.43) | MAPTPTGDR2ALDH1A1MKNK1MKNK2 | |
| SCHEMBL5197304 | 0.83 | MAPT (0.49) | MAPTPTGDR2ALDH1A1MKNK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1799646-B1 | NOVEL PYRIDINONE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2-RECEPTORS | JANSSEN PHARMACEUTICALS INC (US) | 2014-12-10 | — | — | EP | claimed |