Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 12/20 | 0.47 |
| ▸ | ELANE | P08246 | 1/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.44 |
| ▸ | HTR1A | P08908 | 2/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.43 |
| ▸ | HTR2A | P28223 | 2/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.43 |
| ▸ | HTR2B | P41595 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.41 |
| ▸ | SMPD1 | P17405 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2933083 | 0.77 | REN (0.82) | RENHTR1AADRA1DHTR2AADRA1A | |
| SCHEMBL2933081 | 0.77 | REN (0.82) | RENHTR1AADRA1DHTR2AADRA1A | |
| SCHEMBL665128 | 0.77 | HSD17B2 (0.66) | MCHR1MAPK14 | |
| SCHEMBL8251739 | 0.73 | REN (0.55) | RENHTR1AADRA1DHTR2AADRA1A | |
| SCHEMBL2894252 | 0.72 | MAPK14 (0.55) | MAPK14 | |
| SCHEMBL18816698 | 0.72 | HSD17B10 (0.54) | MAPK14 | |
| SCHEMBL4863265 | 0.71 | MAPK14 (0.54) | MAPK14 | |
| SCHEMBL1561587 | 0.71 | PDE4A (0.55) | — | |
| SCHEMBL31053926 | 0.71 | MAPK1 (0.63) | SMPD1 | |
| SCHEMBL88998 | 0.71 | CA12 (0.67) | SMPD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006066896-A2 | PYRROLIDINE DERIVATIVES FOR THE TREATMENT OF A DISEASE DEPENDING ON THE ACTIVITY OF RENIN | NOVARTIS AG (CH) | 2006-06-29 | — | — | WO | disclosed |