SCHEMBL8264754

SCHEMBL8264754

Cc1cc(Cl)ccc1C(=O)NCC1(c2ncccc2F)CCN(S(=O)(=O)c2cn(C)cn2)CC1

nearest known ligand 0.90

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
SLC6A9 P48067 20/20 0.90

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13208130 0.95 SLC6A9 (1.00) SLC6A9
SCHEMBL8264759 0.92 SLC6A9 (0.82) SLC6A9
SCHEMBL8263357 0.92 SLC6A9 (0.77) SLC6A9
SCHEMBL13499794 0.91 SLC6A9 (0.90) SLC6A9
SCHEMBL13499796 0.91 SLC6A9 (0.84) SLC6A9
SCHEMBL13208857 0.90 SLC6A9 (0.85) SLC6A9
SCHEMBL13208536 0.88 SLC6A9 (0.87) SLC6A9
SCHEMBL13499795 0.87 SLC6A9 (0.76) SLC6A9
SCHEMBL13208858 0.87 SLC6A9 (0.78) SLC6A9
SCHEMBL8264785 0.86 SLC6A9 (0.68) SLC6A9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2006067529-A1 PIPERIDINE AND AZETIDINE DERIVATIVES AS GLYT1 INHIBITORS MERCK SHARP & DOHME LIMITED (GB) 2006-06-29 WO disclosed