Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 1/20 | 0.45 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.44 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.39 |
| ▸ | CKS1B | P61024 | 1/20 | 0.38 |
| ▸ | SKP1 | P63208 | 1/20 | 0.38 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8263641 | 0.89 | CHRM2 (0.45) | ESR2NR1H2UCHL1MAPK1USP30 | |
| SCHEMBL8264160 | 0.89 | USP30 (0.47) | ESR2NR1H2UCHL1ADORA1MAPK1 | |
| SCHEMBL8264285 | 0.88 | ESR2 (0.54) | ESR2NR1H2UCHL1ADORA1MAPK1 | |
| SCHEMBL951850 | 0.87 | ESR2 (0.48) | ESR2NR1H2UCHL1ADORA1MAPK1 | |
| SCHEMBL7047941 | 0.87 | SLC6A3 (0.47) | ESR2NR1H2UCHL1ADORA1MAPK1 | |
| SCHEMBL13490542 | 0.87 | ESR2 (0.45) | ESR2NR1H2UCHL1ADORA1MAPK1 | |
| SCHEMBL1752020 | 0.86 | MGAT2 (0.48) | ESR2NR1H2ADORA1USP30ALDH1A1 | |
| SCHEMBL8264295 | 0.81 | MGAT2 (0.42) | ESR2NR1H2UCHL1ADORA1CKS1B | |
| SCHEMBL8264406 | 0.80 | MGAT2 (0.43) | ESR2NR1H2UCHL1ADORA1MAPK1 | |
| SCHEMBL25262018 | 0.79 | ESR2 (0.45) | ESR2NR1H2ADORA1MAPK1GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006074924-A1 | 3,4,(5)-SUBSTITUTED TETRAHVDROPYRIDINES | NOVARTIS AG (CH) | 2006-07-20 | — | — | WO | disclosed |