Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 2/20 | 0.33 |
| ▸ | CTSD | P07339 | 1/20 | 0.33 |
| ▸ | MMP1 | P03956 | 4/20 | 0.32 |
| ▸ | MMP2 | P08253 | 4/20 | 0.32 |
| ▸ | MMP3 | P08254 | 4/20 | 0.32 |
| ▸ | MMP9 | P14780 | 4/20 | 0.32 |
| ▸ | MMP8 | P22894 | 4/20 | 0.32 |
| ▸ | MMP13 | P45452 | 4/20 | 0.32 |
| ▸ | MMP7 | P09237 | 1/20 | 0.32 |
| ▸ | MMP14 | P50281 | 1/20 | 0.32 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.32 |
| ▸ | FEN1 | P39748 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | HTR3A | P46098 | 1/20 | 0.31 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.31 |
| ▸ | FASN | P49327 | 3/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8265936 | 0.80 | POLB (0.41) | KMT2AFASNKDM4EALDH1A1 | |
| SCHEMBL7520536 | 0.77 | KMT2A (0.36) | BACE1CTSDADAM17FEN1KMT2A | |
| SCHEMBL17715590 | 0.72 | ADAMTS5 (0.32) | ADAM17FEN1KMT2APIK3CDHTR3A | |
| SCHEMBL17551591 | 0.71 | FEN1 (0.31) | FEN1KMT2APIK3CDHTR3AHTR4 | |
| SCHEMBL7519592 | 0.71 | SMN1; SMN2 (0.36) | ADAM17KMT2APIK3CDKDM4EALDH1A1 | |
| SCHEMBL17551041 | 0.68 | BACE1 (0.35) | BACE1CTSDKMT2A | |
| SCHEMBL7521703 | 0.67 | SMN1; SMN2 (0.34) | BACE1ADAM17KMT2AFASNALDH1A1 | |
| SCHEMBL7600701 | 0.67 | EPHX1 (0.32) | FEN1PIK3CDHTR3AHTR4EPHX1 | |
| SCHEMBL7553079 | 0.67 | HTT (0.47) | FEN1KMT2AALDH1A1 | |
| SCHEMBL7525542 | 0.67 | FASN (0.39) | FASN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006065277-A2 | HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS | SCHERING CORPORATION (US) | 2006-06-22 | — | — | WO | disclosed |