Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 20/20 | 0.73 |
| ▸ | CYP3A4 | P08684 | 11/20 | 0.73 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8264313 | 0.94 | REN (0.69) | RENCYP3A4KCNH2 | |
| SCHEMBL8263845 | 0.87 | REN (0.61) | RENCYP3A4KCNH2 | |
| SCHEMBL8263665 | 0.86 | REN (0.60) | RENCYP3A4KCNH2 | |
| SCHEMBL8265242 | 0.86 | REN (0.59) | RENCYP3A4KCNH2 | |
| SCHEMBL8265085 | 0.85 | REN (0.57) | RENCYP3A4KCNH2 | |
| SCHEMBL8263738 | 0.85 | REN (0.63) | RENCYP3A4KCNH2 | |
| SCHEMBL8265483 | 0.85 | REN (0.56) | RENCYP3A4KCNH2 | |
| SCHEMBL8263835 | 0.85 | REN (0.59) | RENCYP3A4KCNH2 | |
| SCHEMBL8263684 | 0.84 | REN (0.64) | RENCYP3A4KCNH2 | |
| SCHEMBL3091547 | 0.84 | REN (1.00) | RENCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2177518-A1 | Organic compounds | Novartis AG (CH) | 2010-04-21 | — | — | EP | disclosed |
| EP-1833816-B1 | SUBSTITUTED PIPERIDINES AS RENIN INHIBITORS | NOVARTIS AG (CH) | 2009-11-11 | — | — | EP | disclosed |
| WO-2006069788-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2006-07-06 | — | — | WO | disclosed |