Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.66 |
| ▸ | GAA | P10253 | 9/20 | 0.66 |
| ▸ | RAB9A | P51151 | 7/20 | 0.66 |
| ▸ | NPC1 | O15118 | 6/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.66 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.66 |
| ▸ | MEN1 | O00255 | 8/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.60 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.60 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.60 |
| ▸ | RELA | Q04206 | 2/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | GUSB | P08236 | 1/20 | 0.54 |
| ▸ | MAOA | P21397 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | CASP3 | P42574 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18980779 | 0.84 | MAPT (0.76) | MAPTGAARAB9ANPC1MAPK1 | |
| SCHEMBL18980780 | 0.84 | MAPT (0.76) | MAPTGAARAB9ANPC1MAPK1 | |
| SCHEMBL17150984 | 0.84 | MAPT (0.76) | MAPTGAARAB9ANPC1MAPK1 | |
| SCHEMBL13186607 | 0.77 | MAPT (0.84) | MAPTGAARAB9ANPC1MAPK1 | |
| SCHEMBL1436233 | 0.75 | MAPT (0.79) | MAPTGAARAB9ANPC1MAPK1 | |
| SCHEMBL16742019 | 0.75 | GUSB (0.64) | MAPTGAARAB9ANPC1MAPK1 | |
| SCHEMBL1436231 | 0.75 | MAPT (0.79) | MAPTGAARAB9ANPC1MAPK1 | |
| SCHEMBL16742020 | 0.75 | GUSB (0.64) | MAPTGAARAB9ANPC1MAPK1 | |
| SCHEMBL6721130 | 0.74 | MAPT (0.64) | MAPTGAARAB9ANPC1L3MBTL1 | |
| SCHEMBL28451541 | 0.72 | GAA (0.58) | MAPTGAARAB9ANPC1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006029850-A1 | HYDRAZONE DERIVATIVES AND THEIR USE AS BETA SECRETASE INHIBITORS | THE GENETICS COMPANY, INC. (CH) | 2006-03-23 | — | — | WO | disclosed |