Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 9/20 | 0.67 |
| ▸ | REN | P00797 | 1/20 | 0.56 |
| ▸ | CTSD | P07339 | 1/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.56 |
| ▸ | PDE4A | P27815 | 10/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14922150 | 0.85 | BACE1 (0.51) | BACE1RENCTSDKCNH2PDE4A | |
| SCHEMBL3362527 | 0.78 | BACE1 (0.75) | BACE1RENCTSDKCNH2PDE4A | |
| SCHEMBL12255074 | 0.77 | BACE1 (1.00) | BACE1RENCTSDKCNH2 | |
| SCHEMBL10646995 | 0.74 | PDE4A (0.70) | BACE1RENCTSDKCNH2PDE4A | |
| SCHEMBL3365839 | 0.73 | BACE1 (0.84) | BACE1RENCTSDKCNH2PDE4A | |
| SCHEMBL3393569 | 0.73 | BACE1 (0.73) | BACE1RENCTSDKCNH2PDE4A | |
| SCHEMBL6000198 | 0.73 | BACE1 (0.71) | BACE1RENCTSDKCNH2 | |
| SCHEMBL10646574 | 0.73 | PDE4A (0.70) | BACE1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3363715 | 0.72 | BACE1 (0.81) | BACE1RENCTSDKCNH2PDE4A | |
| SCHEMBL8272278 | 0.72 | BACE1 (0.81) | BACE1RENCTSDKCNH2PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8426429-B2 | 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE) | JANSSSEN PHARMACEUTICA N.V. (BE) | 2013-04-23 | — | — | US | disclosed |
| US-8426429-B2 | 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE) | JANSSSEN PHARMACEUTICA N.V. (BE) | 2013-04-23 | — | — | US | disclosed |
| US-8383637-B2 | 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE) | JANSSSEN PHARMACEUTICA N.V. (BE) | 2013-02-26 | — | — | US | disclosed |
| US-8383637-B2 | 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE) | JANSSSEN PHARMACEUTICA N.V. (BE) | 2013-02-26 | — | — | US | disclosed |
| WO-2006024932-A1 | 2-AMINO-QUINAZOLINE DERIVATIVES USEFUL AS INHIBITORS OF B-SECRETASE (BACE) | JANSSEN PHARMACEUTICA, N.V. (US) | 2006-03-09 | — | — | WO | disclosed |
| WO-2006017844-A1 | NOVEL 2-AMINO-QUINAZOLINE DERIVATIVES USEFUL AS INHIBITORS OF β-SECRETASE (BACE) | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-02-16 | — | — | WO | disclosed |