Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | BCR | P11274 | 1/20 | 0.40 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | PDE2A | O00408 | 2/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
| ▸ | CAMK1D | Q8IU85 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11923288 | 0.85 | ALDH1A1 (0.47) | LMNAABL1BCRTP53PDE2A | |
| SCHEMBL8268278 | 0.83 | ABL1 (0.52) | LMNAABL1BCRPTPN11TP53 | |
| SCHEMBL8267373 | 0.82 | ABL1 (0.51) | LMNAABL1BCRPTPN11TP53 | |
| SCHEMBL8267844 | 0.81 | ABL1 (0.53) | LMNAABL1BCRPTPN11TP53 | |
| SCHEMBL11923375 | 0.79 | KDM4E (0.48) | LMNAABL1BCRPTPN11TP53 | |
| SCHEMBL8267367 | 0.79 | ABL1 (0.45) | LMNAABL1BCRPTPN11TP53 | |
| SCHEMBL8266816 | 0.78 | ABL1 (0.48) | LMNAABL1BCRPTPN11TP53 | |
| SCHEMBL8267648 | 0.77 | PDE4B (0.49) | LMNAABL1BCRPTPN11PDE4B | |
| SCHEMBL2948308 | 0.76 | PTPN11 (0.52) | LMNAABL1BCRPTPN11TP53 | |
| SCHEMBL8265841 | 0.75 | MAPT (0.47) | LMNAABL1BCRTP53KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006050476-A2 | PYRIMIDINE DERIVATIVES AS ION CHANNEL MODULATORS AND METHODS OF USE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2006-05-11 | — | — | WO | disclosed |