Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 1/20 | 0.47 |
| ▸ | FER | P16591 | 1/20 | 0.47 |
| ▸ | LTK | P29376 | 1/20 | 0.47 |
| ▸ | CDK8 | P49336 | 1/20 | 0.47 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.47 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.47 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.47 |
| ▸ | TNKS2 | Q9H2K2 | 6/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | GDA | Q9Y2T3 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5063241 | 0.83 | MGAT2 (0.56) | PDGFRAFERLTKCDK8ACVR1 | |
| SCHEMBL14454673 | 0.83 | ALDH1A1 (0.55) | PDGFRAFERLTKCDK8ACVR1 | |
| SCHEMBL17444761 | 0.83 | ALDH1A1 (0.55) | PDGFRAFERLTKCDK8ACVR1 | |
| SCHEMBL24852681 | 0.82 | KDM4E (0.61) | ALDH1A1KDM4EKMT2AMAPTMEN1 | |
| SCHEMBL5579750 | 0.82 | KDM4E (0.61) | ALDH1A1KDM4EKMT2AMAPTMEN1 | |
| SCHEMBL24852596 | 0.82 | KDM4E (0.61) | ALDH1A1KDM4EKMT2AMAPTMEN1 | |
| SCHEMBL30168111 | 0.82 | KDM4E (0.61) | ALDH1A1KDM4EKMT2AMAPTMEN1 | |
| SCHEMBL14454672 | 0.81 | HSD17B10 (0.64) | PDGFRAFERLTKCDK8ACVR1 | |
| SCHEMBL8871789 | 0.81 | GFER (0.52) | PDGFRAFERLTKCDK8ACVR1 | |
| SCHEMBL8871785 | 0.81 | GFER (0.52) | PDGFRAFERLTKCDK8ACVR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7763605-B2 | [1,4]benzodiazepines as vasopressin V2 receptor antagonists | JANSSEN PHARMACEUTICA, N.V. (BE) | 2010-07-27 | — | — | US | disclosed |
| US-7763605-B2 | [1,4]benzodiazepines as vasopressin V2 receptor antagonists | JANSSEN PHARMACEUTICA, N.V. (BE) | 2010-07-27 | — | — | US | disclosed |
| WO-2006049984-A2 | NOVEL [1,4]BENZODIAZEPINES AS VASOPRESSIN V2 RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-05-11 | — | — | WO | disclosed |