Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | DRD1 | P21728 | 2/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD5 | P21918 | 1/20 | 0.35 |
| ▸ | TIPARP | Q7Z3E1 | 2/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8266921 | 0.91 | PDGFRB (0.50) | PDGFRBPDE10AALDH1A1MAPTPRMT5 | |
| SCHEMBL8267024 | 0.91 | PDE10A (0.39) | PDGFRBPDE10AADRA1DADRA1AADRA1B | |
| SCHEMBL8266829 | 0.90 | TIPARP (0.39) | PDGFRBPDE10AMAPTTIPARPPRMT5 | |
| SCHEMBL5287072 | 0.88 | PDGFRB (0.47) | PDGFRBPDE10AKDM4EALDH1A1MAPT | |
| SCHEMBL8266928 | 0.88 | PDGFRB (0.41) | PDGFRBPDE10ADRD1 | |
| SCHEMBL8265806 | 0.87 | TRPV3 (0.38) | PDGFRBPDE10AMAPTADRA1DADRA1A | |
| SCHEMBL8266918 | 0.87 | PDGFRB (0.39) | PDGFRBPDE10AADRA1DADRA1AADRA1B | |
| SCHEMBL8265764 | 0.87 | PDE10A (0.39) | PDGFRBPDE10AADRA1DADRA1AADRA1B | |
| SCHEMBL5301608 | 0.84 | PDGFRB (0.47) | PDGFRBPDE10AMAPTDRD1DRD2 | |
| SCHEMBL8267157 | 0.83 | PDE10A (0.41) | PDGFRBPDE10ATIPARPPRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006028957-A1 | 4-SUBSTITUTED 4, 6-DIALKOXY-CINNOLINE DERIVATIVES AS PHOSPODIESTERASE 10 INHIBITORS FOR THE TREATMENT OF PSYCHIATRIC OR NEUROLOGICAL SYNDROMS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2006-03-16 | — | — | WO | disclosed |