Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ADRB3 | P13945 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | NPY1R | P25929 | 1/20 | 0.37 |
| ▸ | NPY2R | P49146 | 1/20 | 0.37 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | MME | P08473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7328506 | 0.86 | LMNA (0.47) | LMNAPDE4BPDE4APDE4CPDE4D | |
| SCHEMBL4887950 | 0.84 | HPGD (0.49) | LMNAPDE4BPDE4APDE4CPDE4D | |
| SCHEMBL4884827 | 0.83 | LMNA (0.46) | LMNAPDE4BPDE4APDE4CPDE4D | |
| SCHEMBL4881326 | 0.82 | PDE3B (0.42) | LMNAPDE4BPDE4APDE4CPDE4D | |
| SCHEMBL10867608 | 0.81 | PDE4B (0.48) | LMNAPDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7326426 | 0.79 | PDE3B (0.47) | LMNAPDE4BPDE4APDE4CPDE4D | |
| SCHEMBL10474304 | 0.79 | PDE3B (0.50) | LMNAPDE4BPDE4APDE4CPDE4D | |
| SCHEMBL9657454 | 0.78 | PDE3B (0.45) | LMNAPDE4BPDE4APDE4CPDE4D | |
| SCHEMBL4573757 | 0.77 | PDE3B (0.54) | LMNAPDE4BPDE4APDE4CPDE4D | |
| SCHEMBL10515930 | 0.76 | MEN1 (0.49) | LMNAPDE4BPDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006060127-A2 | COMPOUNDS WITH MIXED PDE-INHIBITORY AND β-ADRENERGIC ANTAGONIST OR PARTIAL AGONIST ACTIVITY FOR TREATMENT OF HEART FAILURE | ARTESIAN THERAPEUTICS, INC. (US) | 2006-06-08 | — | — | WO | disclosed |