Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | CAMK1D | Q8IU85 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.35 |
| ▸ | ATF1 | P18846 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11923203 | 0.84 | GPBAR1 (0.42) | MAPTCAMK1DOPRM1L3MBTL1KDM4E | |
| SCHEMBL11923182 | 0.83 | GPBAR1 (0.42) | MAPTCAMK1DOPRM1L3MBTL1KDM4E | |
| SCHEMBL11923168 | 0.82 | GPBAR1 (0.42) | MAPTCAMK1DOPRM1LMNAL3MBTL1 | |
| SCHEMBL8267650 | 0.82 | GPBAR1 (0.42) | MAPTCAMK1DOPRM1LMNAL3MBTL1 | |
| SCHEMBL8267722 | 0.81 | FFAR1 (0.39) | MAPTCAMK1DOPRM1L3MBTL1KDM4E | |
| SCHEMBL11923243 | 0.80 | FFAR1 (0.39) | MAPTCAMK1DOPRM1POLBL3MBTL1 | |
| SCHEMBL11923297 | 0.80 | GPBAR1 (0.41) | MAPTCAMK1DOPRM1MAPK1TSHR | |
| SCHEMBL11923189 | 0.79 | L3MBTL1 (0.39) | MAPTCAMK1DOPRM1POLBL3MBTL1 | |
| SCHEMBL8266507 | 0.79 | L3MBTL1 (0.39) | MAPTCAMK1DOPRM1POLBL3MBTL1 | |
| SCHEMBL8266187 | 0.78 | MAPT (0.37) | MAPTMAPK1LMNAPOLBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006050476-A2 | PYRIMIDINE DERIVATIVES AS ION CHANNEL MODULATORS AND METHODS OF USE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2006-05-11 | — | — | WO | disclosed |