Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 3/20 | 0.77 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | TOP2A | P11388 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | GBA1 | P04062 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | RECQL | P46063 | 2/20 | 0.51 |
| ▸ | ACP1 | P24666 | 2/20 | 0.51 |
| ▸ | ELANE | P08246 | 1/20 | 0.50 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.49 |
| ▸ | RAD52 | P43351 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8270097 | 0.94 | PDE5A (0.67) | PDE5AMAPTTP53TOP2ASMN1; SMN2 | |
| SCHEMBL8268918 | 0.91 | PDE5A (0.62) | PDE5AMAPTTP53TOP2ASMN1; SMN2 | |
| SCHEMBL1085482 | 0.87 | PDE5A (1.00) | PDE5AMAPTTP53TOP2ASMN1; SMN2 | |
| SCHEMBL8268365 | 0.86 | PDE5A (0.78) | PDE5AMAPTTP53TOP2ASMN1; SMN2 | |
| SCHEMBL8269875 | 0.86 | PDE5A (0.78) | PDE5AMAPTTP53TOP2ASMN1; SMN2 | |
| SCHEMBL8268905 | 0.85 | PDE5A (0.55) | PDE5AMAPTTP53TOP2ASMN1; SMN2 | |
| SCHEMBL8269549 | 0.85 | PDE5A (0.86) | PDE5AMAPTTP53TOP2ASMN1; SMN2 | |
| SCHEMBL8268880 | 0.80 | PDE5A (0.68) | PDE5AMAPTTP53TOP2ASMN1; SMN2 | |
| SCHEMBL8270076 | 0.80 | PDE5A (0.68) | PDE5AMAPTTP53TOP2ASMN1; SMN2 | |
| SCHEMBL8268359 | 0.79 | PDE5A (0.66) | PDE5AMAPTTP53TOP2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006034512-A2 | PHENYL-SUBSTITUTED QUINOLINE AND QUINAZOLINE COMPOUNDS FOR THE TREATMENT OF DIABETES | BAYER PHARMACEUTICALS CORPORATION (US) | 2006-03-30 | — | — | WO | disclosed |