Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 1.00 |
| ▸ | TP53 | P04637 | 5/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 1.00 |
| ▸ | TSHR | P16473 | 5/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | HPGD | P15428 | 2/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.61 |
| ▸ | GBA1 | P04062 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1084138 | 0.93 | MAPT (0.86) | MAPTTP53KDM4ETSHRNPSR1 | |
| SCHEMBL8268364 | 0.87 | MAPT (0.77) | MAPTTP53KDM4ETSHRNPSR1 | |
| SCHEMBL1084150 | 0.86 | MAPT (0.75) | MAPTTP53KDM4ETSHRNPSR1 | |
| SCHEMBL8268371 | 0.85 | MAPT (0.74) | MAPTTP53KDM4ETSHRNPSR1 | |
| SCHEMBL1083969 | 0.83 | MAPT (0.71) | MAPTTP53KDM4ETSHRNPSR1 | |
| SCHEMBL8268369 | 0.83 | MAPT (0.71) | MAPTTP53KDM4ETSHRNPSR1 | |
| SCHEMBL1084000 | 0.82 | MAPT (0.70) | MAPTTP53KDM4ETSHRNPSR1 | |
| SCHEMBL8268372 | 0.81 | MAPT (0.68) | MAPTTP53KDM4ETSHRNPSR1 | |
| SCHEMBL1083809 | 0.80 | TP53 (1.00) | MAPTTP53KDM4ETSHRNPSR1 | |
| SCHEMBL8270962 | 0.78 | TP53 (0.64) | MAPTTP53KDM4ETSHRNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006034512-A2 | PHENYL-SUBSTITUTED QUINOLINE AND QUINAZOLINE COMPOUNDS FOR THE TREATMENT OF DIABETES | BAYER PHARMACEUTICALS CORPORATION (US) | 2006-03-30 | — | — | WO | disclosed |