Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.68 |
| ▸ | TP53 | P04637 | 2/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | TSHR | P16473 | 4/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.47 |
| ▸ | MTOR | P42345 | 2/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.46 |
| ▸ | USP2 | O75604 | 2/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1084138 | 0.84 | MAPT (0.86) | MAPTKDM4ETP53ALDH1A1TSHR | |
| SCHEMBL8268364 | 0.83 | MAPT (0.77) | MAPTKDM4ETP53ALDH1A1TSHR | |
| SCHEMBL8268371 | 0.82 | MAPT (0.74) | MAPTKDM4ETP53ALDH1A1TSHR | |
| SCHEMBL8268367 | 0.81 | MAPT (1.00) | MAPTKDM4ETP53ALDH1A1TSHR | |
| SCHEMBL8270096 | 0.78 | PDE5A (0.58) | MAPTKDM4ETP53ALDH1A1TSHR | |
| SCHEMBL1083969 | 0.78 | MAPT (0.71) | MAPTKDM4ETP53ALDH1A1TSHR | |
| SCHEMBL1084000 | 0.78 | MAPT (0.70) | MAPTKDM4ETP53ALDH1A1TSHR | |
| SCHEMBL8268359 | 0.77 | PDE5A (0.66) | MAPTKDM4ETP53ALDH1A1TSHR | |
| SCHEMBL1084150 | 0.77 | MAPT (0.75) | MAPTKDM4ETP53ALDH1A1TSHR | |
| SCHEMBL8270962 | 0.75 | TP53 (0.64) | MAPTKDM4ETP53ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006034512-A2 | PHENYL-SUBSTITUTED QUINOLINE AND QUINAZOLINE COMPOUNDS FOR THE TREATMENT OF DIABETES | BAYER PHARMACEUTICALS CORPORATION (US) | 2006-03-30 | — | — | WO | disclosed |