Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 20/20 | 0.61 |
| ▸ | TNKS | O95271 | 3/20 | 0.61 |
| ▸ | TNKS2 | Q9H2K2 | 3/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13495551 | 0.87 | PARP1 (0.57) | PARP1 | |
| SCHEMBL15204765 | 0.84 | PARP1 (0.85) | PARP1TNKSTNKS2 | |
| SCHEMBL78096 | 0.84 | PARP1 (0.58) | PARP1TNKSTNKS2 | |
| SCHEMBL8269390 | 0.82 | PARP1 (0.73) | PARP1 | |
| SCHEMBL3353831 | 0.82 | PARP1 (0.71) | PARP1 | |
| SCHEMBL30293105 | 0.81 | PARP1 (0.89) | PARP1TNKSTNKS2 | |
| SCHEMBL2474012 | 0.81 | PARP1 (0.89) | PARP1TNKSTNKS2 | |
| SCHEMBL78374 | 0.80 | PARP1 (0.59) | PARP1 | |
| SCHEMBL78182 | 0.79 | PARP1 (0.58) | PARP1TNKSTNKS2 | |
| SCHEMBL10039729 | 0.79 | PARP1 (0.65) | PARP1TNKSTNKS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7407957-B2 | e.g. 4-[5-(piperazine-1-carbonyl)-furan-2-ylmethyl]-2H-phthalazin-1-one; enzyme poly(ADP-ribose)polymerase (synthase)-1 or poly ADP-ribosyltransferase (PARP-1) inhibitor; anticarcinogenic agent; septic shock; ischemic injury; reperfusion injury; hemorrhagic shock; and multiple sclerosis | MAYBRIDGE LIMITED (GB) | 2008-08-05 | — | — | US | disclosed |
| US-7407957-B2 | e.g. 4-[5-(piperazine-1-carbonyl)-furan-2-ylmethyl]-2H-phthalazin-1-one; enzyme poly(ADP-ribose)polymerase (synthase)-1 or poly ADP-ribosyltransferase (PARP-1) inhibitor; anticarcinogenic agent; septic shock; ischemic injury; reperfusion injury; hemorrhagic shock; and multiple sclerosis | MAYBRIDGE LIMITED (GB) | 2008-08-05 | — | — | US | disclosed |
| WO-2006021801-A1 | 4-HETEROARYLMETHYL SUBSTITUTED PHTHALAZINONE DERIVATIVES | KUDOS PHARMACEUTICALS LIMITED (GB) | 2006-03-02 | — | — | WO | disclosed |