⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3123627 | 0.81 | IDO1 (0.61) | — | |
| SCHEMBL30675253 | 0.79 | RAPGEF4 (0.61) | — | |
| SCHEMBL392473 | 0.79 | RAPGEF4 (0.61) | — | |
| SCHEMBL26186322 | 0.79 | NPC1 (0.50) | — | |
| SCHEMBL27972189 | 0.77 | — | — | |
| SCHEMBL29909163 | 0.75 | — | — | |
| SCHEMBL306546 | 0.75 | — | — | |
| SCHEMBL357210 | 0.75 | — | — | |
| SCHEMBL1143757 | 0.75 | — | — | |
| SCHEMBL16416590 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0527154-A1 | PROCESS FOR PREPARING 3,4-DIFLUOROANILINE | Pfizer Hospital Products Group, Inc. (US) | 1993-02-17 | — | — | EP | claimed |
| WO-1991017138-A1 | PROCESS FOR PREPARING 3,4-DIFLUOROANILINE | PFIZER INC. (US) | 1991-11-14 | — | — | WO | claimed |
| US-11724982-B2 | Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2023-08-15 | — | — | US | disclosed |
| US-11724982-B2 | Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2023-08-15 | — | — | US | disclosed |
| US-11724982-B2 | Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2023-08-15 | — | — | US | disclosed |
| US-20200262784-A1 | TRIFLUOROMETHOXYLATION OF ARENES VIA INTRAMOLECULAR TRIFLUOROMETHOXY GROUP MIGRATION | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2020-08-20 | — | — | US | disclosed |
| US-20200262784-A1 | TRIFLUOROMETHOXYLATION OF ARENES VIA INTRAMOLECULAR TRIFLUOROMETHOXY GROUP MIGRATION | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2020-08-20 | — | — | US | disclosed |
| US-10676424-B2 | Trifluoromethoylation of arenes via intramolecular trifluoromethoxy group migration | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2020-06-09 | — | — | US | disclosed |
| US-10676424-B2 | Trifluoromethoylation of arenes via intramolecular trifluoromethoxy group migration | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2020-06-09 | — | — | US | disclosed |
| CN-107207515-B | Pyrazine compounds for the treatment of infectious diseases | 豪夫迈·罗氏有限公司 | 2019-05-28 | — | — | CN | disclosed |
| US-20190016670-A1 | TRIFLUOROMETHOXYLATION OF ARENES VIA INTRAMOLECULAR TRIFLUOROMETHOXY GROUP MIGRATION | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2019-01-17 | — | — | US | disclosed |
| EP-0527154-A1 | PROCESS FOR PREPARING 3,4-DIFLUOROANILINE | Pfizer Hospital Products Group, Inc. (US) | 1993-02-17 | — | — | EP | disclosed |
| US-5120741-A | Crop protection against phytopathogenic microorganisms | CIBA-GEIGY CORPORATION (US) | 1992-06-09 | — | — | US | disclosed |
| WO-1991017138-A1 | PROCESS FOR PREPARING 3,4-DIFLUOROANILINE | PFIZER INC. (US) | 1991-11-14 | — | — | WO | disclosed |
| WO-1991017138-A1 | PROCESS FOR PREPARING 3,4-DIFLUOROANILINE | PFIZER INC. (US) | 1991-11-14 | — | — | WO | disclosed |
| EP-0441747-A2 | Microbicide agent | CIBA-GEIGY AG (CH) | 1991-08-14 | — | — | EP | disclosed |
| US-4224340-A | Anti-inflammatory compositions containing α-phenyl-N-phenylnitrone compounds | WILLIAM H. RORER, INC. (US) | 1980-09-23 | — | — | US | disclosed |
| US-4214003-A | ANTIINFLAMMATORY AGENTS | WILLIAM H. RORER, INC. (US) | 1980-07-22 | — | — | US | disclosed |
| US-4197314-A | WITH A DIPHENYL NITRONE | WILLIAM H. RORER, INC. (US) | 1980-04-08 | — | — | US | disclosed |
| US-4153722-A | ANTIINFLAMMATORY, A-PHENYL-N-PHENYLNITRONE | WILLIAM H. RORER, INC. (US) | 1979-05-08 | — | — | US | disclosed |