SCHEMBL8272012

SCHEMBL8272012

CC#CCn1c(N(C)C[C@H](C)N)nc2c1c(=O)n(Cc1ncccc1N)c(=O)n2C

nearest known ligand 0.44

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
DPP4 P27487 18/20 0.44
DPP9 Q86TI2 1/20 0.40
TRPA1 O75762 1/20 0.39
CHRM1 P11229 1/20 0.38
FAP Q12884 3/20 0.38
HTT P42858 1/20 0.37
HSD17B10 Q99714 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4483972 0.90 DPP4 (0.46) DPP4DPP9CHRM1
SCHEMBL4483980 0.90 DPP4 (0.46) DPP4DPP9CHRM1
SCHEMBL8271558 0.89 DPP4 (0.46) DPP4DPP9CHRM1FAP
SCHEMBL8273204 0.88 DPP4 (0.45) DPP4DPP9CHRM1FAPHTT
SCHEMBL8273201 0.87 DPP4 (0.44) DPP4DPP9CHRM1FAPHTT
SCHEMBL9290388 0.86 DPP4 (0.49) DPP4DPP9CHRM1FAP
SCHEMBL8271563 0.85 DPP4 (0.48) DPP4DPP9CHRM1FAP
SCHEMBL8273229 0.85 DPP4 (0.40) DPP4TRPA1FAP
SCHEMBL8273235 0.85 DPP4 (0.45) DPP4DPP9CHRM1FAP
SCHEMBL9290400 0.85 DPP4 (0.43) DPP4DPP9CHRM1FAP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2006029769-A1 NOVEL 3-METHYL-7-BUTINYL-XANTHINES, PRODUCTION THEREOF, AND USE THEREOF AS MEDICAMENTS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2006-03-23 WO disclosed