Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOS1 | Q07889 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.35 |
| ▸ | CA12 | O43570 | 3/20 | 0.35 |
| ▸ | CA2 | P00918 | 3/20 | 0.35 |
| ▸ | CA7 | P43166 | 3/20 | 0.35 |
| ▸ | CA9 | Q16790 | 3/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | CFTR | P13569 | 1/20 | 0.35 |
| ▸ | CA3 | P07451 | 1/20 | 0.35 |
| ▸ | CA6 | P23280 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8273124 | 0.85 | CA12 (0.41) | ALDH1A1KDM4EHPGDHSD17B10CA12 | |
| SCHEMBL1674226 | 0.81 | KMT2A (0.41) | ALDH1A1KDM4EHPGDHSD17B10CA12 | |
| SCHEMBL2840089 | 0.78 | MAPK1 (0.54) | ALDH1A1KDM4EHSD17B10MAPTGAA | |
| SCHEMBL8273120 | 0.75 | ALDH1A1 (0.49) | ALDH1A1KDM4EHPGDHSD17B10CA12 | |
| SCHEMBL26985505 | 0.75 | ALDH1A1 (0.48) | ALDH1A1KDM4EHPGDHSD17B10CA12 | |
| SCHEMBL8273126 | 0.71 | ALDH1A1 (0.40) | SOS1ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL26985518 | 0.69 | GAA (0.36) | ALDH1A1KDM4EHPGDCA2CA9 | |
| SCHEMBL5860698 | 0.69 | KDM4E (0.46) | ALDH1A1KDM4EHSD17B10MAPTGAA | |
| SCHEMBL2109561 | 0.69 | HSD17B10 (0.44) | ALDH1A1KDM4EHPGDHSD17B10CA12 | |
| SCHEMBL23577866 | 0.69 | SOS1 (0.41) | SOS1ALDH1A1KDM4EHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7511062-B2 | Substituted 2-quinolyl-oxazoles useful as PDE4 inhibitors | SCHERING CORPORATION (US) | 2009-03-31 | — | — | US | disclosed |
| US-7511062-B2 | Substituted 2-quinolyl-oxazoles useful as PDE4 inhibitors | SCHERING CORPORATION (US) | 2009-03-31 | — | — | US | disclosed |
| WO-2005116009-A1 | SUBSTITUTED 2-QUINOLYL-OXAZOLES USEFUL AS PDE4 INHIBITORS | SCHERING CORPORATION (US) | 2005-12-08 | — | — | WO | disclosed |