Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 11/20 | 0.51 |
| ▸ | HCRTR1 | O43613 | 7/20 | 0.51 |
| ▸ | PKM | P14618 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.43 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.43 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.43 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.43 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.43 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.43 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3255521 | 0.92 | PKM (0.48) | HCRTR2HCRTR1PKMPOLBMCOLN3 | |
| SCHEMBL3255886 | 0.90 | PKM (0.48) | HCRTR2HCRTR1PKMPOLBMCOLN3 | |
| SCHEMBL3252995 | 0.90 | PKM (0.47) | HCRTR2HCRTR1PKMPOLBMCOLN3 | |
| SCHEMBL3254966 | 0.90 | PKM (0.47) | HCRTR2HCRTR1PKMPOLBMCOLN3 | |
| SCHEMBL3251551 | 0.90 | HCRTR2 (0.49) | HCRTR2HCRTR1PKMPOLBMCOLN3 | |
| SCHEMBL3251964 | 0.90 | PKM (0.49) | HCRTR2HCRTR1PKMPOLBMCOLN3 | |
| SCHEMBL3243770 | 0.90 | PKM (0.47) | HCRTR2HCRTR1PKMPOLBMCOLN3 | |
| SCHEMBL3255534 | 0.89 | HCRTR2 (0.45) | HCRTR2HCRTR1PKMPOLBMCOLN3 | |
| SCHEMBL3256098 | 0.89 | PKM (0.47) | HCRTR2HCRTR1PKMPOLBMCOLN3 | |
| SCHEMBL3256512 | 0.89 | PKM (0.56) | HCRTR2HCRTR1PKMPOLBMCOLN3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1776347-B1 | SULPHONAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION | SANOFI AVENTIS (FR) | 2010-05-26 | — | — | EP | disclosed |
| WO-2006024779-A1 | SULPHONAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION | SANOFI-AVENTIS (FR) | 2006-03-09 | — | — | WO | disclosed |