Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 9/20 | 0.61 |
| ▸ | NAMPT | P43490 | 2/20 | 0.45 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 5/20 | 0.41 |
| ▸ | DRD4 | P21917 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.39 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.39 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | THPO | P40225 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8274846 | 1.00 | ADAM17 (0.61) | ADAM17NAMPTCHRM4DRD2DRD4 | |
| SCHEMBL8213991 | 0.94 | ADAM17 (0.55) | ADAM17NAMPTCHRM4DRD2DRD4 | |
| SCHEMBL8213656 | 0.90 | ADAM17 (0.54) | ADAM17NAMPTCHRM4MEN1KMT2A | |
| SCHEMBL8276637 | 0.90 | ADAM17 (0.53) | ADAM17NAMPTDRD2DRD4TAS1R3 | |
| SCHEMBL8221362 | 0.90 | ADAM17 (0.66) | ADAM17CHRM4DRD2DRD4DRD3 | |
| SCHEMBL8222661 | 0.89 | ADAM17 (0.53) | ADAM17CHRM4MEN1KMT2A | |
| SCHEMBL8221255 | 0.87 | ADAM17 (0.55) | ADAM17NAMPTCHRM4MEN1KMT2A | |
| SCHEMBL8222707 | 0.87 | ADAM17 (0.49) | ADAM17NAMPTMEN1KMT2AADAM10 | |
| SCHEMBL8221026 | 0.87 | ADAM17 (0.51) | ADAM17NAMPTCHRM4DRD2MEN1 | |
| SCHEMBL8221408 | 0.87 | ADAM17 (0.51) | ADAM17NAMPTCHRM4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005121130-A2 | CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM FOR THE TREATMENT OF INFLAMMATORY DISORDERS | SCHERING CORPORATION (US) | 2005-12-22 | — | — | WO | disclosed |