Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7548624 | 0.98 | ATM (0.65) | ATMKMT2AL3MBTL1MEN1TDP1 | |
| SCHEMBL4812065 | 0.94 | ATM (0.65) | ATMKMT2AL3MBTL1MEN1TDP1 | |
| SCHEMBL22623120 | 0.94 | ATM (0.59) | ATMKMT2AL3MBTL1MEN1TDP1 | |
| SCHEMBL29236351 | 0.88 | ATM (0.50) | ATMKMT2AL3MBTL1MEN1TDP1 | |
| SCHEMBL3498067 | 0.86 | ATM (0.58) | ATMKMT2AL3MBTL1MEN1TDP1 | |
| SCHEMBL10722542 | 0.85 | ATM (0.85) | ATMKMT2AL3MBTL1MEN1TDP1 | |
| SCHEMBL28366947 | 0.85 | ATM (0.85) | ATMKMT2AL3MBTL1MEN1TDP1 | |
| SCHEMBL27487132 | 0.85 | ATM (0.85) | ATMKMT2AL3MBTL1MEN1TDP1 | |
| SCHEMBL5530068 | 0.84 | ATM (0.60) | ATMKMT2AL3MBTL1MEN1TDP1 | |
| SCHEMBL10722543 | 0.83 | ATM (0.81) | ATMKMT2AL3MBTL1MEN1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006008259-A1 | DIMERIC COMPOUNDS OF PIPERIDINE, PIPERAZINE OR MORPHOLINE OR THEIR 7-MEMBERED ANALOGS SUITABALE FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-01-26 | — | — | WO | disclosed |