Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 1/20 | 0.46 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | MGLL | Q99685 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 2/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.35 |
| ▸ | MAP2 | P11137 | 1/20 | 0.35 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.35 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 2/20 | 0.35 |
| ▸ | APAF1 | O14727 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | CASP6 | P55212 | 1/20 | 0.34 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL826935 | 0.85 | FFAR1 (0.44) | FFAR1KITALDH1A1KDM4EGLA | |
| SCHEMBL824929 | 0.82 | FFAR1 (0.45) | FFAR1KITMGLLPOLBNPSR1 | |
| SCHEMBL827610 | 0.82 | FFAR1 (0.44) | FFAR1KITMGLLPOLBNPSR1 | |
| SCHEMBL824728 | 0.82 | FFAR1 (0.43) | FFAR1KITMGLLPOLBNPSR1 | |
| Trifluoroacetic Acid SCHEMBL828181 | 0.81 | FFAR1 (0.45) | FFAR1KITMGLLPOLBNPSR1 | |
| SCHEMBL2710616 | 0.81 | FFAR1 (0.43) | FFAR1KITMGLLPOLBNPSR1 | |
| SCHEMBL828336 | 0.80 | TNKS (0.48) | POLBNPSR1ALDH1A1KDM4EGLA | |
| SCHEMBL827108 | 0.80 | AR (0.36) | FFAR1NPSR1ALDH1A1KDM4ETNKS | |
| SCHEMBL824740 | 0.80 | FFAR1 (0.41) | FFAR1KITMGLLPOLBNPSR1 | |
| SCHEMBL827978 | 0.78 | FFAR1 (0.42) | FFAR1KITALDH1A1KDM4EGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143274-B2 | 1-(2H)-isoquinolone derivative | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2012-03-27 | — | — | US | disclosed |