Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 4/20 | 0.48 |
| ▸ | OXTR | P30559 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 2/20 | 0.42 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.42 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.42 |
| ▸ | APAF1 | O14727 | 1/20 | 0.41 |
| ▸ | CASP6 | P55212 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | PARP1 | P09874 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.37 |
| ▸ | TUBB | P07437 | 1/20 | 0.37 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.37 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.37 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL826935 | 0.82 | FFAR1 (0.44) | TNKSCASP3SENP8SENP7SENP6 | |
| SCHEMBL827412 | 0.80 | FFAR1 (0.46) | TNKSCASP3SENP8SENP7SENP6 | |
| SCHEMBL824702 | 0.79 | TNKS (0.58) | TNKSKDM4EPARP1MAPT | |
| SCHEMBL828014 | 0.79 | APAF1 (0.40) | CASP3SENP8SENP7APAF1MAPT | |
| SCHEMBL824671 | 0.78 | TNKS (0.48) | TNKSCASP3SENP8SENP7SENP6 | |
| SCHEMBL824665 | 0.78 | TNKS (0.44) | TNKSCASP3SENP8SENP7SENP6 | |
| SCHEMBL824608 | 0.77 | TNKS (0.53) | TNKSCASP3SENP8SENP7SENP6 | |
| SCHEMBL827108 | 0.77 | AR (0.36) | TNKSKDM4EPPARGALDH1A1NPSR1 | |
| SCHEMBL9084339 | 0.76 | TNKS (0.48) | TNKSKDM4EPARP1MAPTALDH1A1 | |
| SCHEMBL824731 | 0.76 | TNKS (0.44) | TNKSCASP3SENP8SENP7SENP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143274-B2 | 1-(2H)-isoquinolone derivative | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2012-03-27 | — | — | US | disclosed |