Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 13/20 | 0.52 |
| ▸ | MTTP | P55157 | 2/20 | 0.45 |
| ▸ | MMP12 | P39900 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8276794 | 0.86 | ADAM17 (0.45) | ADAM17MTTPEGFR | |
| SCHEMBL8220615 | 0.84 | ADAM17 (0.48) | ADAM17MTTPEPHX2 | |
| SCHEMBL8222002 | 0.83 | ADAM17 (0.54) | ADAM17MTTP | |
| SCHEMBL8273724 | 0.83 | ADAM17 (0.49) | ADAM17MTTP | |
| SCHEMBL8275467 | 0.82 | ADAM17 (0.38) | ADAM17MMP12 | |
| SCHEMBL8223839 | 0.81 | ADAM17 (0.51) | ADAM17MTTP | |
| SCHEMBL8215093 | 0.80 | ADAM17 (0.48) | ADAM17MTTP | |
| SCHEMBL13542436 | 0.80 | ADAM17 (0.46) | ADAM17MTTP | |
| SCHEMBL8223831 | 0.79 | ADAM17 (0.48) | ADAM17MTTP | |
| SCHEMBL13542435 | 0.79 | ADAM17 (0.51) | ADAM17MTTP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005121130-A2 | CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM FOR THE TREATMENT OF INFLAMMATORY DISORDERS | SCHERING CORPORATION (US) | 2005-12-22 | — | — | WO | disclosed |