Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 9/20 | 0.43 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.39 |
| ▸ | MMP12 | P39900 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 3/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.37 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.37 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8275593 | 0.89 | ADAM17 (0.43) | ADAM17MEN1KMT2ANAMPTHDAC8 | |
| SCHEMBL8221255 | 0.86 | ADAM17 (0.55) | ADAM17ADAM10MMP12MMP13MEN1 | |
| SCHEMBL8275600 | 0.82 | ADAM17 (0.45) | ADAM17ADAM10MMP12MMP13MEN1 | |
| SCHEMBL8274403 | 0.81 | GRIN2D (0.43) | ADAM17MEN1KMT2ANAMPT | |
| SCHEMBL8274451 | 0.80 | ADAM17 (0.45) | ADAM17ADAM10MMP12MMP13MEN1 | |
| SCHEMBL8275194 | 0.79 | ADAM17 (0.42) | ADAM17MEN1KMT2ANAMPTHDAC8 | |
| SCHEMBL8275183 | 0.79 | ADAM17 (0.43) | ADAM17MEN1KMT2ANAMPT | |
| SCHEMBL8274407 | 0.79 | ADAM17 (0.43) | ADAM17MEN1KMT2ANAMPT | |
| SCHEMBL8276118 | 0.79 | ADAM17 (0.43) | ADAM17MEN1KMT2ANAMPT | |
| SCHEMBL13544350 | 0.79 | ADAM17 (0.47) | ADAM17ADAM10MMP12MMP13MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005121130-A2 | CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM FOR THE TREATMENT OF INFLAMMATORY DISORDERS | SCHERING CORPORATION (US) | 2005-12-22 | — | — | WO | disclosed |