Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 20/20 | 0.57 |
| ▸ | PDE11A | Q9HCR9 | 2/20 | 0.52 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.52 |
| ▸ | PDE4A | P27815 | 2/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8275269 | 0.86 | PDE4B (0.51) | PDE4BPDE11APDE10APDE3A | |
| SCHEMBL8275376 | 0.82 | PDE4B (0.51) | PDE4BPDE11APDE10APDE4APDE4C | |
| SCHEMBL8275375 | 0.80 | PDE4B (0.47) | PDE4BPDE11APDE10APDE4APDE4C | |
| SCHEMBL8275273 | 0.80 | PDE4B (0.46) | PDE4BPDE11APDE10APDE3A | |
| SCHEMBL13920549 | 0.80 | PDE4B (0.66) | PDE4BPDE11APDE10A | |
| SCHEMBL8274722 | 0.80 | PDE4B (0.52) | PDE4BPDE11APDE10APDE3A | |
| SCHEMBL13920546 | 0.80 | PDE4B (0.58) | PDE4BPDE11APDE10A | |
| SCHEMBL8274034 | 0.79 | PDE4B (0.84) | PDE4BPDE11APDE10A | |
| SCHEMBL5207914 | 0.77 | PDE4B (0.65) | PDE4BPDE11APDE10APDE4APDE4C | |
| SCHEMBL8274724 | 0.77 | PDE4B (0.52) | PDE4BPDE11APDE10APDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7511062-B2 | Substituted 2-quinolyl-oxazoles useful as PDE4 inhibitors | SCHERING CORPORATION (US) | 2009-03-31 | — | — | US | disclosed |
| US-7511062-B2 | Substituted 2-quinolyl-oxazoles useful as PDE4 inhibitors | SCHERING CORPORATION (US) | 2009-03-31 | — | — | US | disclosed |
| WO-2005116009-A1 | SUBSTITUTED 2-QUINOLYL-OXAZOLES USEFUL AS PDE4 INHIBITORS | SCHERING CORPORATION (US) | 2005-12-08 | — | — | WO | disclosed |