Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 3/20 | 0.48 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 2/20 | 0.36 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29438175 | 1.00 | CYP1A2 (0.48) | CYP1A2CYP2A6ADRA2AADRA2BNR4A2 | |
| SCHEMBL28147434 | 0.81 | ADRA2A (0.46) | CYP1A2CYP2A6ADRA2AADRA2BHTR1A | |
| SCHEMBL28227987 | 0.77 | SLC22A12 (0.47) | CYP2A6HTR1ADRD2HTR2ACYP19A1 | |
| SCHEMBL5153625 | 0.75 | ADRA2A (0.56) | CYP2A6ADRA2AADRA2BHTR1ADRD2 | |
| SCHEMBL8114338 | 0.73 | ADRA2A (0.42) | CYP2A6ADRA2AADRA2BHTR1ADRD2 | |
| SCHEMBL24611290 | 0.71 | ADRA2A (0.41) | CYP2A6ADRA2AADRA2BHTR1ADRD2 | |
| SCHEMBL3794962 | 0.71 | ADRA2A (0.41) | ADRA2AADRA2BHTR1ADRD2HTR2A | |
| SCHEMBL276421 | 0.71 | ADRA2A (0.41) | CYP2A6ADRA2AADRA2BHTR1ADRD2 | |
| SCHEMBL3791942 | 0.71 | ADRA2A (0.44) | CYP2A6ADRA2AADRA2BHTR1ADRD2 | |
| SCHEMBL289078 | 0.71 | ADRA2A (0.41) | CYP2A6ADRA2AADRA2BHTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 115 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115073420-A | Preparation method of 2-phenylbenzothiophene derivative | 陕西维世诺新材料有限公司 | 2022-09-20 | — | — | CN | claimed |
| CN-114249720-A | Preparation method of brexpiprazole | 南京佰麦生物技术有限公司 | 2022-03-29 | — | — | CN | claimed |
| CN-119462500-A | Preparation method of 7- (4-chlorobutoxy) -1H-quinolin-2-one | 湖南省湘中制药有限公司 | 2025-02-18 | — | — | CN | disclosed |
| CN-118580229-B | Preparation method of bripiprazole | 湖南一格制药有限公司 | 2024-12-27 | — | — | CN | disclosed |
| CN-115894434-B | Preparation method of 4-piperazinyl benzothiophene hydrochloride | 山东厚德精诚药业有限公司 | 2024-10-08 | — | — | CN | disclosed |
| CN-118580229-A | Preparation method of bripiprazole | 湖南一格制药有限公司 | 2024-09-03 | — | — | CN | disclosed |
| CN-117946066-A | Synthesis method of bripiprazole intermediate | 江苏宇锐医药科技有限公司 | 2024-04-30 | — | — | CN | disclosed |
| CN-117624120-A | Preparation method of bripiprazole intermediate | 重庆圣华曦药业股份有限公司 | 2024-03-01 | — | — | CN | disclosed |
| CN-115677655-B | Synthesis method of epinastine intermediate | 湖南省湘中制药有限公司 | 2023-12-08 | — | — | CN | disclosed |
| CN-114082449-B | Preparation method and application of aluminum ligand catalyst | 万华化学集团股份有限公司 | 2023-10-17 | — | — | CN | disclosed |
| CN-115894434-A | Preparation method of 4-piperazinyl benzothiophene hydrochloride | 山东厚德精诚药业有限公司 | 2023-04-04 | — | — | CN | disclosed |
| US-5846982-A | Inhibition of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1998-12-08 | — | — | US | disclosed |
| WO-1998025611-A1 | SULFONIC ACID OR SULFONYLAMINO N-(HETEROARALKYL)-AZAHETEROCYCLYLAMIDE COMPOUNDS | RHÔNE-POULENC RORER PHARMACEUTICALS INC. (US) | 1998-06-18 | — | — | WO | disclosed |
| WO-1998024784-A1 | SUBSTITUTED SULFONIC ACID N-[(AMINOIMINOMETHYL)PHENYLALKYL]-AZAHETEROCYCLAMIDE COMPOUNDS | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1998-06-11 | — | — | WO | disclosed |
| WO-1997047302-A1 | INHIBITION OF SEROTONIN REUPTAKE | ELI LILLY AND COMPANY (US) | 1997-12-18 | — | — | WO | disclosed |
| EP-0812826-A1 | 1H-indole and benzo(b)thiophene derivatives with 4-(1,2,3,6-tetra:hydro:pyridinyl)- and 4-piperidinyl-groups bound to the heterocyclic ring as inhibitors of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1997-12-17 | — | — | EP | disclosed |
| US-5627196-A | ANTIDEPRESSANTS AND ANTISEROTONIN AGENTS | ELI LILLY AND COMPANY (US) | 1997-05-06 | — | — | US | disclosed |
| US-5614523-A | INDOLYLOXY COMPOUNDS | ELI LILLY AND COMPANY (US) | 1997-03-25 | — | — | US | disclosed |
| US-5576321-A | ALKOXY-SUBSTITUTED INDOLES | ELI LILLY AND COMPANY (US) | 1996-11-19 | — | — | US | disclosed |
| EP-0722941-A2 | Compounds having effects on serotonin-related systems | ELI LILLY AND COMPANY (US) | 1996-07-24 | — | — | EP | disclosed |