Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 11/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.38 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.38 |
| ▸ | OXTR | P30559 | 1/20 | 0.38 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8217800 | 1.00 | ADAM17 (0.54) | ADAM17HIF1AOPRM1OPRK1USP30 | |
| SCHEMBL8210470 | 0.90 | ADAM17 (0.49) | ADAM17HIF1AUSP30AVPR2OXTR | |
| SCHEMBL8213691 | 0.81 | ADAM17 (0.69) | ADAM17 | |
| SCHEMBL8223934 | 0.80 | ADAM17 (0.47) | ADAM17OPRM1OPRK1ABL1 | |
| SCHEMBL8210486 | 0.80 | ADAM17 (0.62) | ADAM17 | |
| SCHEMBL8276676 | 0.80 | ADAM17 (0.62) | ADAM17 | |
| SCHEMBL8274421 | 0.80 | ADAM17 (0.43) | ADAM17USP30ABL1RET | |
| SCHEMBL8213654 | 0.80 | ADAM17 (0.79) | ADAM17 | |
| SCHEMBL8219908 | 0.80 | ADAM17 (0.79) | ADAM17 | |
| SCHEMBL8276921 | 0.80 | ADAM17 (0.55) | ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005121130-A2 | CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM FOR THE TREATMENT OF INFLAMMATORY DISORDERS | SCHERING CORPORATION (US) | 2005-12-22 | — | — | WO | disclosed |