Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CTSD | P07339 | 6/20 | 0.38 |
| ▸ | BACE1 | P56817 | 6/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.37 |
| ▸ | BRD4 | O60885 | 2/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.36 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8279283 | 1.00 | GAA (0.40) | GAACTSDBACE1TRPV1BRD4 | |
| SCHEMBL25824938 | 0.87 | GAA (0.40) | GAACTSDBACE1TRPV1BRD4 | |
| SCHEMBL12709612 | 0.86 | TRPV1 (0.45) | GAACTSDBACE1TRPV1 | |
| SCHEMBL4146006 | 0.86 | AAK1 (0.41) | GAACTSDBACE1TRPV1SIRT2 | |
| SCHEMBL8122445 | 0.86 | TRPV1 (0.48) | CTSDBACE1TRPV1 | |
| SCHEMBL803760 | 0.85 | GAA (0.39) | GAACTSDBACE1TRPV1NFKB1 | |
| SCHEMBL4135566 | 0.84 | KDM4E (0.40) | GAACTSDBACE1TRPV1BRD4 | |
| SCHEMBL12731042 | 0.84 | CTSD (0.45) | GAACTSDBACE1TRPV1BRD4 | |
| SCHEMBL803515 | 0.84 | KDM4D (0.43) | GAACTSDBACE1TRPV1NFKB1 | |
| SCHEMBL7986840 | 0.84 | BRD4 (0.48) | GAATRPV1BRD4CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005087714-A2 | METHODS OF TREATMENT OF AMYLOIDOSIS USING BI-CYCLIC ASPARTYL PROTEASE INHIBITORS | ELAN PHARMACEUTICALS, INC. (US) | 2005-09-22 | — | — | WO | disclosed |