Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 18/20 | 0.64 |
| ▸ | DPP8 | Q6V1X1 | 6/20 | 0.64 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3149261 | 0.78 | DPP4 (1.00) | DPP4DPP8CYP3A4 | |
| SCHEMBL3149775 | 0.75 | KDM4E (0.45) | DPP4DPP8PARP1 | |
| SCHEMBL3149686 | 0.74 | DPP4 (0.60) | DPP4DPP8CYP3A4 | |
| SCHEMBL3149198 | 0.70 | DPP4 (1.00) | DPP4DPP8 | |
| SCHEMBL3149462 | 0.70 | DPP4 (0.57) | DPP4DPP8 | |
| SCHEMBL1995841 | 0.69 | DPP4 (0.46) | DPP4DPP8CYP3A4 | |
| SCHEMBL3145087 | 0.69 | DPP4 (1.00) | DPP4DPP8 | |
| SCHEMBL2000319 | 0.68 | DPP4 (0.45) | DPP4DPP8PARP1 | |
| SCHEMBL23841441 | 0.66 | ACP1 (0.35) | PARP1 | |
| SCHEMBL5174933 | 0.66 | DPP4 (0.69) | DPP4DPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7687638-B2 | Dipeptidyl peptidase inhibitors | TAKEDA SAN DIEGO, INC. (US) | 2010-03-30 | — | — | US | disclosed |
| US-7687638-B2 | Dipeptidyl peptidase inhibitors | TAKEDA SAN DIEGO, INC. (US) | 2010-03-30 | — | — | US | disclosed |
| WO-2005118555-A1 | DIPEPTIDYL PEPTIDASE INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2005-12-15 | — | — | WO | disclosed |