Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB3 | P13945 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.34 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.32 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3970666 | 0.94 | ADRB3 (0.43) | ADRB3ADRA2BADRA2CPOLBALDH1A1 | |
| SCHEMBL3970663 | 0.94 | ADRB3 (0.43) | ADRB3ADRA2BADRA2CPOLBALDH1A1 | |
| SCHEMBL3970669 | 0.94 | ADRB3 (0.43) | ADRB3ADRA2BADRA2CPOLBALDH1A1 | |
| SCHEMBL8294162 | 0.92 | ADRB3 (0.45) | ADRB3ADRA2BADRA2CPOLBALDH1A1 | |
| SCHEMBL13610494 | 0.90 | CTSB (0.39) | ADRB3ADRA2BADRA2CPOLBALDH1A1 | |
| SCHEMBL3975313 | 0.90 | CTSB (0.39) | ADRB3ADRA2BADRA2CPOLBALDH1A1 | |
| SCHEMBL4219729 | 0.90 | ADRB3 (0.44) | ADRB3ADRA2BADRA2CPOLBALDH1A1 | |
| SCHEMBL4219726 | 0.90 | ADRB3 (0.44) | ADRB3ADRA2BADRA2CPOLBALDH1A1 | |
| SCHEMBL4219723 | 0.90 | ADRB3 (0.44) | ADRB3ADRA2BADRA2CPOLBALDH1A1 | |
| SCHEMBL13896386 | 0.89 | ADRB3 (0.43) | ADRB3ADRA2BADRA2CPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005095403-A2 | MACROCYCLIC COMPOUNDS AS INHIBITORS OF VIRAL REPLICATION | INTERMUNE, INC. (US) | 2005-10-13 | — | — | WO | disclosed |