Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 3/20 | 0.53 |
| ▸ | NOS3 | P29474 | 1/20 | 0.46 |
| ▸ | NOS1 | P29475 | 1/20 | 0.46 |
| ▸ | NOS2 | P35228 | 1/20 | 0.46 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.42 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.42 |
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.39 |
| ▸ | F10 | P00742 | 3/20 | 0.38 |
| ▸ | TDO2 | P48775 | 1/20 | 0.37 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.37 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8290925 | 0.80 | CYP2D6 (0.49) | CYP1A2CYP2C19 | |
| SCHEMBL8280206 | 0.80 | DPP4 (0.50) | DPP4NOS3NOS1NOS2PRMT5 | |
| SCHEMBL30607577 | 0.79 | DPP4 (0.49) | DPP4NOS3NOS1NOS2NPC1 | |
| SCHEMBL14007487 | 0.79 | DPP4 (0.49) | DPP4NPC1PKMTDO2CYP2A6 | |
| SCHEMBL30332418 | 0.78 | DPP4 (0.47) | DPP4NOS3NOS1NOS2F10 | |
| SCHEMBL1038044 | 0.76 | DPP4 (0.69) | DPP4NOS3NOS1NOS2NPC1 | |
| SCHEMBL16814937 | 0.76 | DPP4 (0.49) | DPP4NOS3NOS1NOS2 | |
| SCHEMBL27806948 | 0.76 | DPP4 (0.53) | DPP4NOS3NOS1NOS2F10 | |
| SCHEMBL3288789 | 0.75 | DPP4 (0.62) | DPP4PTGS2TDO2CYP1A2CYP2E1 | |
| SCHEMBL4446323 | 0.74 | HPGD (0.50) | PDK2HPGDSNPC1PKMRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005090354-A1 | PYRAZOLO[3,4-b] PYRIDINE COMPOUNDS, AND THEIR USE AS PDE4 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2005-09-29 | — | — | WO | disclosed |