Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 3/20 | 0.50 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.44 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.44 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
| ▸ | NOS3 | P29474 | 1/20 | 0.41 |
| ▸ | NOS1 | P29475 | 1/20 | 0.41 |
| ▸ | NOS2 | P35228 | 1/20 | 0.41 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 2/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | ATR | Q13535 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.35 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.35 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.35 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21116042 | 0.81 | TRPA1 (0.37) | TRPA1ALOX5APFEN1PTGS1PTGS2 | |
| SCHEMBL8279412 | 0.80 | DPP4 (0.53) | DPP4PRMT5WDR77TRPA1NOS3 | |
| SCHEMBL30607577 | 0.79 | DPP4 (0.49) | DPP4NOS3NOS1NOS2 | |
| SCHEMBL31359602 | 0.78 | HPGD (0.45) | ALOX5APFEN1PTGS1PTGS2GRM5 | |
| SCHEMBL14007487 | 0.76 | DPP4 (0.49) | DPP4LOXL2 | |
| SCHEMBL30332418 | 0.75 | DPP4 (0.47) | DPP4TRPA1NOS3NOS1NOS2 | |
| SCHEMBL26040044 | 0.74 | PRMT5 (0.46) | PRMT5WDR77PTGS1PTGS2 | |
| SCHEMBL10271458 | 0.73 | RAB9A (0.45) | PRMT5WDR77 | |
| SCHEMBL16814937 | 0.73 | DPP4 (0.49) | DPP4NOS3NOS1NOS2 | |
| SCHEMBL9498645 | 0.73 | LMNA (0.38) | PRMT5WDR77TRPA1PTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005090354-A1 | PYRAZOLO[3,4-b] PYRIDINE COMPOUNDS, AND THEIR USE AS PDE4 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2005-09-29 | — | — | WO | disclosed |