Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 12/20 | 0.67 |
| ▸ | ABCB11 | O95342 | 3/20 | 0.66 |
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | USP2 | O75604 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.58 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11187981 | 1.00 | ACE (0.67) | ACEABCB11LMNAMEN1KMT2A | |
| SCHEMBL11035895 | 0.91 | ACE (0.73) | ACEABCB11LMNAMEN1KMT2A | |
| SCHEMBL11049974 | 0.91 | ACE (0.73) | ACEABCB11LMNAMEN1KMT2A | |
| SCHEMBL11050512 | 0.91 | ACE (0.73) | ACEABCB11LMNAMEN1KMT2A | |
| SCHEMBL11050522 | 0.91 | ACE (0.73) | ACEABCB11LMNAMEN1KMT2A | |
| SCHEMBL11049962 | 0.91 | ACE (0.73) | ACEABCB11LMNAMEN1KMT2A | |
| SCHEMBL11177491 | 0.88 | ACE (0.69) | ACEABCB11LMNAMEN1KMT2A | |
| SCHEMBL11101516 | 0.88 | ACE (0.73) | ACEABCB11LMNAMEN1KMT2A | |
| SCHEMBL11106730 | 0.88 | ACE (0.73) | ACEABCB11LMNAMEN1KMT2A | |
| SCHEMBL7279512 | 0.88 | ACE (0.73) | ACEABCB11LMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005079772-A2 | COMBINATION OF (S)-AMLODIPINE AND AN ACE INHIBITOR, AND METHODS FOR REDUCING HYPERTENSION | SEPRACOR INC. (US) | 2005-09-01 | — | — | WO | disclosed |